Bedside Snapshot
- Recognize
- Some dehydration: about 3–6% weight loss; alert but thirsty or irritable.
Moderate to severe: 6% or more; lethargic, sunken eyes, absent tears, dry mucosa, capillary refill over 2 s. - Red Flags
- Lethargy, limp or not consolable
- Capillary refill over 2 s
- Any sign of shock or hypotension
- Little or no urine output
- First Actions
- Airway, oxygen, IV or IO access if perfusion is poor, glucose check, and a measured or estimated weight. With adequate perfusion, start oral or NG rehydration; give an isotonic bolus for shock or poor perfusion.
- Key Doses
- Isotonic crystalloid 10–20 mL/kg bolus for shock or poor perfusion, reassess after each
- Oral rehydration 75 mL/kg over 4 hr (some or moderate dehydration, adequate perfusion)
- Ondansetron 0.15 mg/kg PO (max 8 mg)
- Don't Miss
- Sepsis, diabetic ketoacidosis, hypoglycemia and ingestion presenting as vomiting or altered mental status. Hypotonic fluid causing hyponatremia.
- Escalate & Transport
- PICU or pediatric-ready ED for shock, altered mental status, or failed oral and IV rehydration. Transfer with a fluid log and a structured handoff.
Overview & Pediatric Differences
Dehydration means losing water and electrolytes, usually through vomiting, diarrhea, fever or poor intake. Kids lose fluid faster than adults, with less in reserve. A modest deficit can change perfusion and mental status fast. Your job has three parts: estimate the deficit, restore perfusion with the right fluid, and avoid changing sodium too fast.
Why Kids Are Different
- Small reserve: in an infant, a few hundred milliliters is a large share of circulating volume.
- Heart rate is the early response: stroke volume is capped by heart size. Tachycardia comes before hypotension.
- Weight change is the reference: validation studies estimate the deficit from weight loss against a known baseline. Most field weights, though, are estimates.
- Isotonic fluid is the default: AAP 2018 recommends isotonic solutions for children aged 28 days to 18 years who need maintenance fluid. Hypotonic fluid raises the risk of hyponatremia.
Recognition & Severity
Grade dehydration from the bedside signs. If a baseline weight exists, use the weight change too. The validation studies use different cut points. Falszewska 2018 puts some dehydration at 3–6% weight loss and moderate to severe at 6% or more. Gorelick 1997 used 5% or more. Treat the table as a bedside guide, not a precise percentage. The grade picks the route. A child with adequate perfusion starts with oral or NG rehydration. Poor perfusion, shock or failed enteral therapy needs IV or IO (see Management by Severity).
| Feature | Some Dehydration (3–6%) | Moderate to Severe (6% or more) |
|---|---|---|
| Mental status | Alert, thirsty or irritable | Lethargic, drowsy or limp; hard to console |
| Eyes | Normal | Sunken |
| Tears | Present | Absent |
| Mucous membranes | Moist | Dry |
| Capillary refill | 2 s or less | Over 2 s |
| Urine output | Reduced | Little or none; ask about the last wet diaper |
| Heart rate | Raised | Marked tachycardia; bradycardia with poor perfusion is a pre-arrest sign |
Gorelick 1997 derived the any-two-of-four rule: capillary refill over 2 s, absent tears, dry mucous membranes and ill general appearance. The derivation used 186 children aged 1 month to 5 years. Two or more of these signs predicted a deficit of at least 5%. Individual signs have low sensitivity. The diagnosis rests on several findings together. A later systematic review did not confirm the Gorelick scale in most validation studies. It also found little value in the WHO scale. Use these rules as a rough guide per Falszewska 2018.
Differential Diagnosis
Usually it's vomiting and diarrhea. The trap is the look-alikes: several must-not-miss conditions present the same way.
| Condition | Distinguishing Features | Key Test or Finding |
|---|---|---|
| Acute gastroenteritis | Vomiting and diarrhea, sick contacts, fever in some children | Stool pattern and intake history; antibiotics are not routine (see Management) |
| Diabetic ketoacidosis | Polyuria, polydipsia, deep breathing, vomiting | Point-of-care glucose and ketones; treat per the DKA protocol |
| Sepsis | Fever or hypothermia, altered mental status, poor perfusion | Treat as sepsis when perfusion fails; see the pediatric sepsis page |
| Hypoglycemia | Altered mental status, poor intake, sweating | Glucose check in every child with altered mental status |
| Ingestion or toxic cause | Unexplained vomiting or decline in mental status | Exposure history; check glucose and treat per toxicology guidance |
Management by Severity
Some or Moderate Dehydration With Adequate Perfusion: Oral or NG Rehydration
- Start oral rehydration solution: 75 mL/kg over 4 hours (WHO plan B), in small frequent amounts, per local protocol. Guidelines differ on volume, so follow local protocol. ESPGHAN/ESPID 2014 calls enteral rehydration superior to IV rehydration. Rapid rehydration over 4 hours is effective (2013 Pieścik-Lech review). Replace ongoing stool and vomit losses per protocol. Keep breastfeeding or a normal diet going as tolerated. Refuses, or cannot keep up with oral intake? A nasogastric tube is an accepted route, per local protocol. Avoid loperamide and other antimotility agents in children with gastroenteritis.
- Treat vomiting that stops intake: ondansetron as in Medications & Dosing. It reduces vomiting, but it's off-label for gastroenteritis in the US.
- Reassess at 4 hours: weight, perfusion, urine output and mental status. Choose discharge, or move to IV rehydration if oral or NG therapy has failed or perfusion is poor.
- Do not give antibiotics for uncomplicated gastroenteritis: empirical antibiotics are reserved for these cases: infants under 3–6 months with suspected bacterial illness, underlying disease, sepsis, or institutional settings, per the 2025 Spanish consensus.
Shock, Poor Perfusion or Severe Dehydration: IV or IO Rehydration
- Give an isotonic bolus: 10–20 mL/kg IV or IO, reassess after each (Paramedic/RN/CCT, per local protocol). Use IV or IO for shock or poor perfusion, severe dehydration, ileus or vomiting that prevents enteral intake, or failed oral or NG rehydration. Don't start IV access for a moderately dehydrated child who has adequate perfusion and can take ORS. The Pieścik-Lech 2013 review judged 20 mL/kg an appropriate IV volume in gastroenteritis, until more data are in. The Pediatric Shock page and local protocol set the bolus volume and reassessment.
- Reassess after each bolus: mental status, capillary refill, heart rate, blood pressure, urine output, lung exam and work of breathing.
- Repeat until perfusion recovers: stop for crackles, hepatomegaly or rising oxygen need. Above 20 mL/kg in the first hour, you're making a shock decision. See the Pediatric Shock page.
- Check glucose and replace ongoing losses: treat hypoglycemia per the Dextrose page, then start maintenance fluid once perfusion is restored.
Medications & Dosing
| Drug | Dose & Route | Max | Notes |
|---|---|---|---|
| Isotonic crystalloid (0.9% NaCl or lactated Ringer's) | 10–20 mL/kg IV/IO bolus for shock or poor perfusion, reassess after each; infusion rate per the Pediatric Shock page and local protocol | No fixed max: titrate to perfusion; stop for overload | Balanced crystalloid is suggested over saline in sepsis (see Pediatric Shock). Lactated Ringer's contains calcium. See Normal Saline and Lactated Ringer's |
| Maintenance IV fluid, isotonic, 4-2-1 rule High-alert when potassium is added | 4 mL/kg/hr for the first 10 kg, 2 mL/kg/hr for the next 10 kg, 1 mL/kg/hr for each kg over 20; IV, with dextrose and potassium per order | Typical adult cap about 100 mL/hr (2.4 L/day); confirm per protocol | Example: 14 kg child = 40 + 8 = 48 mL/hr. Isotonic default for ages 28 days to 18 years, per AAP 2018. Add potassium only after urine output is confirmed and serum K⁺ is known, per order. The AAP guideline excludes neurosurgical, cardiac, hepatic, renal, oncologic and diabetes insipidus patients, neonates under 28 days, severe burns, and voluminous watery diarrhea; follow protocol for those. |
| Oral rehydration solution | 75 mL/kg PO over 4 hr (WHO plan B) for some or moderate dehydration with adequate perfusion, small frequent amounts, plus replacement of ongoing losses per protocol. NG route if oral intake fails | 75 mL/kg over 4 hr, then reassess | Use a reduced-osmolarity pediatric oral rehydration solution per local protocol (sodium about 45–60 mmol/L is the common recommendation). Guidelines differ on volume, so follow local protocol. Reassess at 4 hr before more volume. Once perfusion is restored, resume ORS or feeding as tolerated. |
| Ondansetron | 0.15 mg/kg PO. Weight-based: 8–15 kg 2 mg; over 15–30 kg 4 mg; over 30 kg 6–8 mg | Single ED dose, max 8 mg | Off-label in the US for gastroenteritis. ODT comes only as 4 or 8 mg, so use the oral solution (4 mg/5 mL) for 2 mg or 6 mg doses. Start oral rehydration 15–30 min after the dose. Studied in children about 6 months to 10 years with gastroenteritis per Freedman 2006; the US label covers oral use from age 4 for chemotherapy-related nausea. Not routine when diarrhea is the main symptom. Contraindicated with hypersensitivity and with apomorphine. Avoid in congenital long QT syndrome; caution with other QT-prolonging or serotonergic drugs (serotonin syndrome). |
Doses vary by protocol; follow local protocols and medical direction.
Monitoring, Reassessment & Disposition
| Parameter | Target | Notes |
|---|---|---|
| Perfusion | Capillary refill 2 s or less; warm extremities; normal mental status | Recheck after each bolus |
| Urine output | Passing urine regularly | Ask about the last wet diaper; reduced output is an early sign |
| Weight | Trend from baseline | Reweigh at 4 hr on oral therapy; the deficit estimate depends on it |
| Glucose | Normal for age | Treat hypoglycemia per the Dextrose page |
| Serum sodium | Changing within the limits below | Repeat Na⁺ with each IV change in hospital settings |
Sodium Correction Limits
- Hyponatremia: These limits come from an adult nephrology standard (Spasovski 2024, reported in mmol/L). They are not pediatric guidance. In children, a pediatric nephrologist or intensivist should direct correction. For acute or severe symptomatic cases, the goal is a rise of 4–6 mEq/L in the first 6 hr. The rise should not exceed 8 mEq/L in any later 24-hr period. Here's the trap: a rise of more than 10 mEq/L in the first 24 hr is the level most often linked to osmotic demyelination. In vaptan-treated patients, the same standard caps high-risk patients at 8 mEq/L. Examples: hypokalemia, alcoholism, malnutrition or liver disease.
- Hypernatremia of chronic or unknown duration: Restore perfusion with isotonic fluid first. Then lower Na⁺ by no more than 0.5 mEq/L per hour and 10 mEq/L per 24 hr. These are commonly used targets, not pediatric guideline values (see the 0.45% Sodium Chloride page).
Disposition
- Discharge: perfusion normal and keeping fluids down after the oral plan, per local protocol.
- Admit or transfer: failed oral or IV rehydration, persistent shock, altered mental status, or sodium that needs controlled correction.
Pitfalls & Safety Checks
| Pitfall | Consequence | Prevention |
|---|---|---|
| Hypotonic maintenance fluid | Hyponatremia | Isotonic maintenance for ages 28 days to 18 years, per AAP 2018 |
| Sodium changed too fast | Osmotic demyelination with rapid correction of hyponatremia | Check Na⁺ on repeat draws and stay within the limits above |
| Relying on blood pressure | Shock is missed while the child is compensating | Use mental status, capillary refill, pulses and urine output |
| Missing hypoglycemia or DKA | Altered mental status is wrongly blamed on dehydration | Check glucose in every child with altered mental status |
| Antibiotics for uncomplicated gastroenteritis | Adverse effects without benefit | Reserve for the indications listed in Management by Severity |
| Repeated boluses without reassessment | Fluid overload and crackles | Reassess after each bolus and stop for overload |
| Estimated weight used as fact | Wrong bolus and maintenance volume | Use measured weight when possible; see Broselow for length-based estimates |
Special Populations
Infants
- Small reserve: a short illness can mean a large deficit. Weigh the infant whenever possible.
- Antibiotics are kept for infants under 3–6 months with suspected bacterial illness, per the 2025 Spanish consensus.
Children With Heart or Kidney Disease
- Give smaller boluses and reassess more often. The Lactated Ringer's page makes the same point for heart failure and end-stage kidney disease.
- Stop fluid for crackles, hepatomegaly or rising oxygen need.
Adolescents
- Use adult fluid volumes once the weight rule on the Weight-Based Dosing page is met.
Children With Diabetes
- Vomiting with high glucose: treat as possible DKA and follow the DKA protocol.
- Hypoglycemia can look like dehydration. Check glucose first.
Prehospital & Transport Considerations
| Level | Typical Role in This Topic |
|---|---|
| EMT | Assess perfusion and mental status, check glucose, and give oral fluids when the protocol allows |
| AEMT | Establish IV or IO access and give an isotonic bolus, per protocol |
| Paramedic | Isotonic bolus, ondansetron and maintenance rate; estimate weight when none is recorded |
| RN (ED/ICU) | Monitor intake and output, run IV fluids, and check sodium |
| Critical Care Transport | Run a fluid log, maintain the infusion and transport the child to a pediatric-ready ED or PICU |
Commonly, these roles are set by state or agency protocol. Know your local scope before you act.
- Equipment: pediatric weight tape or length-based tool, pre-measured bolus volumes, and a pump that delivers mL/hr.
- Destination: pediatric-ready ED for dehydration with shock or failed oral therapy; PICU for shock or sodium needing controlled correction.
- Handoff: use IMIST-AMBO or MIST, with the weight, the total volume given, the sodium and glucose, and the urine output.
Clinical Pearls
References
- Feld LG, Neuspiel DR, Foster BA, et al. Clinical practice guideline: maintenance intravenous fluids in children. Pediatrics. 2018;142(6):e20183083. https://doi.org/10.1542/peds.2018-3083
- Gorelick MH, Shaw KN, Murphy KO. Validity and reliability of clinical signs in the diagnosis of dehydration in children (landmark study). Pediatrics. 1997;99(5):E6. https://doi.org/10.1542/peds.99.5.e6
- Falszewska A, Szajewska H, Dziechciarz P. Diagnostic accuracy of three clinical dehydration scales: a systematic review. Arch Dis Child. 2018;103(4):383–388. https://doi.org/10.1136/archdischild-2017-313762
- Berghezan-Suárez A, López-Martín D, Carbajo Ferreira ÁJ, et al. Consensus document of the SEIP/AEPap/SEPEAP/SEGHNP/SEUP on the diagnosis and etiological treatment of infectious acute gastroenteritis. An Pediatr (Engl Ed). 2025;103(4):503984. https://doi.org/10.1016/j.anpede.2025.503984
- Pieścik-Lech M, Shamir R, Guarino A, Szajewska H. Review article: the management of acute gastroenteritis in children. Aliment Pharmacol Ther. 2013;37(3):289–303. https://doi.org/10.1111/apt.12163
- Spasovski G. Hyponatraemia-treatment standard 2024. Nephrol Dial Transplant. 2024;39(10):1583–1592. https://doi.org/10.1093/ndt/gfae162
- Freedman SB, Adler M, Seshadri R, Powell EC. Oral ondansetron for gastroenteritis in a pediatric emergency department. N Engl J Med. 2006;354(16):1698–1705. https://doi.org/10.1056/NEJMoa055119
- Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H. ESPGHAN/ESPID evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr. 2014. https://doi.org/10.1097/MPG.0000000000000375
Medical Disclaimer
- For Educational Purposes Only: This content is intended for educational reference and should not be used for clinical decision-making.
- Not a Substitute for Professional Judgment: Always consult your local protocols, institutional guidelines, and supervising physicians.
- Verify Before Acting: Users are responsible for verifying information through authoritative sources before any clinical application.