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About This Panel

The cardiac panel is a collection of blood tests used to evaluate heart function and diagnose cardiac conditions. These biomarkers are essential in the assessment of acute coronary syndrome (ACS), myocardial infarction, heart failure, and other cardiovascular emergencies.

Modern cardiac biomarkers have revolutionized the diagnosis and risk stratification of patients presenting with chest pain and suspected cardiac events. Understanding the timing, sensitivity, and specificity of each marker is crucial for appropriate clinical interpretation.

Clinical Applications

  • Acute Coronary Syndrome (ACS): Primary use in diagnosing STEMI, NSTEMI, and unstable angina
  • Myocardial Injury: Detection of cardiac damage from trauma, sepsis, or other non-ischemic causes
  • Heart Failure: Assessment of decompensated heart failure and volume status
  • Risk Stratification: Prognostic information for cardiac patients
  • Serial Monitoring: Tracking progression or resolution of cardiac events

Individual Cardiac Markers

Troponin I & T

Normal: <0.04 ng/mL (varies by assay)

Gold standard biomarker for myocardial injury. Highly sensitive and specific for detecting cardiac damage. Essential for ACS diagnosis and risk stratification.

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BNP / NT-proBNP

BNP: <100 pg/mL | NT-proBNP: <125 pg/mL

Natriuretic peptides released in response to ventricular stretch. Primary marker for heart failure diagnosis and assessment of fluid overload.

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CK-MB

Normal: <5% of total CK or <25 IU/L

Creatine kinase MB isoenzyme. Traditional cardiac marker, now largely replaced by troponin. Useful for detecting reinfarction and procedural complications.

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Myoglobin

Normal: 20-80 ng/mL

Early marker of muscle injury released within hours of myocardial damage. High sensitivity but low specificity. Useful for early rule-out of MI.

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