Bedside Snapshot
- Use It For
- RSI paralysis, especially when succinylcholine is contraindicated; routine intubation; continued paralysis for controlled ventilation (OR, ICU, transport)
- Adult Dose
- RSI: 1–1.2 mg/kg IV/IO rapid push (max 1.2 mg/kg)
- Repeat: 0.1–0.2 mg/kg IV once twitches return
- Infusion: 10–12 mcg/kg/min, titrate 4–16 mcg/kg/min
- Pediatric Dose
- Intubation: 0.6 mg/kg IV (label; IO at the same dose per emergency practice). Emergency RSI: 1 mg/kg IV/IO (off-label; max 1.2 mg/kg). Differs from FDA label: label does not recommend pediatric RSI use
- Onset / Duration
- IV: ~1 min / median 60–70 min after 1–1.2 mg/kg (range to 160 min; 94 min at 1.2 mg/kg if ≥65 yr); about 30 min after 0.6 mg/kg; longer in liver disease
- Do Not Give / Hold If
- Anaphylaxis to any neuromuscular blocker; no airway plan, rescue equipment or ventilation ready; sedation not ready; no twitch on train-of-four (no repeat dose)
- Watch For
- Awareness under paralysis (rising HR or BP, tearing); anaphylaxis (hypotension, bronchospasm); residual block after extubation (TOF ratio <0.9)
- Reversal / Rescue
- Sugammadex 2 mg/kg (2nd twitch back) or 4 mg/kg (1–2 post-tetanic counts); adults: 16 mg/kg for immediate reversal after 1.2 mg/kg. Ventilate until recovered
- Must Remember
- Paralysis outlasts the induction agent: rocuronium has no sedative or analgesic effect. Start analgosedation right after tube confirmation, and store it segregated: wrong-drug errors kill
Indications
Emergency & Prehospital
- Rapid sequence intubation (RSI): paralysis right after the induction agent (see RSI)
- RSI when succinylcholine is contraindicated: hyperkalemia risk, malignant hyperthermia susceptibility, neuromuscular disease, denervation, or burns and crush injury past the first day
- Continued paralysis after intubation: transport or transfer when ventilation is controlled and sedation is deep
ED / ICU / Transport
- Routine intubation and facilitating ventilation: the label lists it as an FDA-labeled adjunct to general anesthesia, and long-term ICU use has not been studied per the label. In the ICU, think short trial: life-threatening hypoxemia, respiratory acidosis or hemodynamic compromise. Optimize sedation and ventilator settings first, per SCCM 2016 guidance
- Severe ARDS: not routine. ESICM 2023 recommends against routine NMBA infusions in moderate-to-severe non-COVID ARDS (strong, moderate evidence). ATS 2024 conditionally suggests them only in early severe ARDS (low certainty). The large trials used cisatracurium, not rocuronium. Reserve it for refractory hypoxemia or dyssynchrony, and keep the course short
- Overt shivering during targeted temperature management: when other measures fail (weak SCCM 2016 suggestion)
Other Uses
- Surgical muscle relaxation: maintenance by repeat bolus or infusion under general anesthesia (FDA-labeled; anesthesia-directed)
Dosing & Administration
Doses vary by protocol; follow local protocols and medical direction. Where a dose departs from the FDA label, it's marked.
Available Forms
- 10 mg/mL multiple-dose vials: 50 mg in 5 mL and 100 mg in 10 mL; the common refrigerated product (Hospira label)
- 10 mg/mL single-dose vials or prefilled syringe: 50 mg in 5 mL and 100 mg in 10 mL vial; the Fresenius Kabi NDA 217472 product is stored at 20–25 °C, so follow the package storage line
High-Alert Medication: Rocuronium stops breathing. Wrong patient, wrong drug or no sedation can be fatal. Store it segregated, with the warning cap and ferrule intact. Label every syringe as a paralyzing agent. Before every push, check the drug, the dose in mg and mg/kg, and the weight.
Adult Dosing
| Indication | Dose & Route | Repeat / Max | Notes |
|---|---|---|---|
| RSI (emergency) | 1–1.2 mg/kg IV/IO rapid push, right after the induction agent | Single dose; max 1.2 mg/kg (label RSI range 0.6–1.2 mg/kg; no labeled absolute cap) | High-alert Dosing weight: actual body weight per the label (obesity: see Special Populations). 1.2 mg/kg gives the fastest onset and longest duration. Draw up post-intubation sedation first. |
| Routine (non-RSI) intubation | 0.6 mg/kg IV | Single dose; 0.45 mg/kg with some anesthetic techniques | High-alert Intubating block in about 1 min; clinical duration median 31 min (15–85). |
| Maintenance / repeat bolus | 0.1–0.2 mg/kg IV | Only after recovery is evident (label doses given at 25% T1 recovery, about 3 of 4 twitches); titrate to TOF | High-alert Give sedation first if any sign of light sedation. |
| Starting paralysis, intubated and unparalyzed (ICU/transport) | 0.6 mg/kg IV loading dose once deep sedation is confirmed; then infusion 10–12 mcg/kg/min at early recovery, or 0.1–0.2 mg/kg IV once twitches return | Single loading dose (labeled intubating doses run to 1.2 mg/kg); then titrate to TOF | High-alert A 0.1–0.2 mg/kg maintenance dose alone underdoses a fully recovered patient. Label CABG study: 8 mcg/kg/min for 6–12 hr. After succinylcholine, give only once its recovery is seen. |
Pediatric Dosing
| Indication | Dose (per kg) & Route | Max Single / Max Total | Notes |
|---|---|---|---|
| Intubation (labeled) | 0.6 mg/kg IV (0.45 mg/kg by technique and age); IO at the same dose per emergency practice (off-label) | Single dose; not above the adult dose | High-alert Block in about 1 min; median clinical duration 26 min (age 1–12 yr), 41 min (3–12 months). |
| Emergency RSI (off-label) | 1 mg/kg IV/IO (source: Bisesi 2024 pediatric RSI practice study) | Single dose; max 1.2 mg/kg (not above the adult dose) | High-alert Differs from FDA label: label does not recommend rocuronium for pediatric RSI; labeled intubating dose 0.6 mg/kg. Use measured or length-based weight (Broselow). |
| Maintenance | 0.075–0.15 mg/kg IV once twitches return; or infusion 7–12 mcg/kg/min | No fixed max: titrate to TOF | High-alert Infusion needs are lowest in neonates and highest at age 2–11 yr. |
| Neonates (birth to 28 days) | Same per-kg doses (0.45–1 mg/kg studied, label Table 6) | Single dose; NICU or specialist direction | High-alert Slowest onset, longest duration. See weight-based dosing. |
Continuous Infusion
| Setting | Example Concentration | Start | Titrate | Usual Range / Max |
|---|---|---|---|---|
| OR / ICU / transport, adult | 1 mg/mL: 100 mg in 100 mL (example, institution-specific) | 10–12 mcg/kg/min, only after early spontaneous recovery from the intubating or loading dose | Commonly 1–2 of 4 twitches, read with clinical signs, not TOF alone | 4–16 mcg/kg/min in label trials; needs often fall after 4–8 hr, but tolerance can develop over days |
| Pediatric | 0.5–1 mg/mL (example, institution-specific) | 7–12 mcg/kg/min once 1–2 twitches return | To TOF | Titrate to effect: no fixed max |
Preparation & Administration
- Push and sequence: Give it undiluted as a rapid IV push. Label studies gave doses over 5 sec. Then flush. Induction agent first, rocuronium right after. Draw up the post-intubation sedation beforehand.
- Dilution: Mix to 0.5–5 mg/mL in NS, D5W, D5NS, lactated Ringer's or sterile water. Use within 24 hr. Never run it in one line with alkaline drugs such as barbiturates. Flush between drugs. If it extravasates, restart in another vein.
- IO and pumps: When there's no IV, give the same dose IO. That is off-label emergency practice, and the label route is IV only. See IO access. Run infusions on a smart pump with a drug library, and label the line and bag as a paralyzing agent.
Contraindications & Precautions
Contraindications
- Known hypersensitivity (e.g., anaphylaxis) to rocuronium or any other neuromuscular blocker. Cross-reactivity between depolarizing and nondepolarizing agents is reported.
- No ability to ventilate: don't give it unless intubation, ventilation, oxygen and a reversal agent are immediately available (label warning).
Precautions
- Anticipated difficult airway: the median block lasts 60–70 min after an RSI dose (about 94 min at 1.2 mg/kg in adults 65 and older). Spontaneous ventilation won't return in time to rescue a failed airway. Have a failed-airway plan, front-of-neck access and sugammadex ready.
- Myasthenia gravis or Lambert-Eaton syndrome: small doses can have profound effects. Reduce the dose and guide it with TOF.
- Potentiation: cachexia, carcinomatosis, neuromuscular disease. Severe acid-base or electrolyte disorders can deepen or blunt the block.
- Resistance: burns, denervation, disuse atrophy, muscle trauma, cerebral palsy, chronic phenytoin or carbamazepine, and prolonged ICU infusion (apparent tolerance).
- Pulmonary hypertension or valvular heart disease: may raise pulmonary vascular resistance.
- Cesarean section RSI: not recommended by the label (a small 0.6 mg/kg study had poor intubating conditions in 5 of 13 women).
- Ventilated status asthmaticus (relative): SCCM suggests against routine paralytic use. Corticosteroids add myopathy risk.
Hold / Reassess If
- No twitch on TOF: do not redose; reduce or pause the infusion until at least 1 twitch returns
- Rising HR or BP, tearing or sweating under paralysis: give analgesia and sedation first
- Every day on an infusion: reassess the need and stop as soon as gas exchange allows
- Before withdrawal of life support or brain-death testing: stop the paralytic (SCCM)
Adverse Effects & Toxicity
Common
- Transient hypotension or hypertension: about 2% in European trials, 0.1% in US trials
- Tachycardia: mild vagolytic effect; transient with laryngoscopy in about one-third of adults; 5.3% in pediatric studies
- Histamine-type signs (flushing, rash, bronchospasm): 0.8%
- Less than 1%: arrhythmia, nausea, vomiting, hiccup, pruritus, injection-site edema
- QTc prolongation: seen in children given rocuronium with general anesthetics. A direct drug effect was not shown.
Serious / Life-Threatening
| Effect | Recognition | Management |
|---|---|---|
| Awareness with paralysis | Rising HR or BP, tearing, sweating; recall of being awake and unable to move after extubation | Start analgosedation right after tube confirmation and redose on schedule; ask about recall after extubation and refer for support |
| Anaphylaxis | Hypotension, bronchospasm, rising airway pressures, rash (may be hidden under drapes) | Stop further doses. Epinephrine IM at the anaphylaxis dose on its page, repeated if no improvement. IV fluids and airway support. Refractory: IV epinephrine infusion (boluses only by clinicians experienced in vasopressor titration). Refer for allergy testing; avoid all NMBAs until evaluated. Fluid and anaphylaxis background: anaphylaxis page (cites 2025 AHA Part 10) |
| Prolonged or residual block | Weak cough or head lift, shallow breathing or desaturation after extubation, TOF ratio <0.9 | Ventilate; reverse with sugammadex; confirm TOF ratio ≥0.9 before extubation |
| ICU-acquired weakness / myopathy | Weakness when weaning after prolonged infusion, especially with corticosteroids | Shortest effective duration; daily reassessment; structured physiotherapy |
| Corneal exposure injury | Incomplete lid closure, corneal dryness or abrasion during infusions | Scheduled lubricating drops or gel and eyelid closure (SCCM strong recommendation) |
| Malignant hyperthermia (rare; not a known trigger) | Rising EtCO₂ despite more ventilation, tachycardia, rising temperature | Stop triggering agents; dantrolene per the MH protocol |
Overdose & Toxicity Management
- Signs and management: paralysis that outlasts the intended time, hypoventilation, or airway obstruction after extubation. Secure the airway, control ventilation and keep the patient sedated until recovery is confirmed.
- Antidote: sugammadex IV, dosed by actual body weight: 2 mg/kg once the second twitch returns, or 4 mg/kg at 1–2 post-tetanic counts with no TOF twitch. In adults only, 16 mg/kg gives immediate reversal about 3 min after 1.2 mg/kg rocuronium. Not studied in children. Labeled for surgical patients. ICU, ED or transport use is off-label. Pediatric doses are on the sugammadex page. Watch for marked bradycardia and anaphylaxis, and have atropine ready (Bridion label).
- Neostigmine: neostigmine with an anticholinergic, and only at minimal depth (TOF ratio 0.4 to <0.9). It cannot reverse deep block.
- Re-paralysis after sugammadex: waiting times before rocuronium or vecuronium is given again are on the sugammadex page. Need paralysis sooner? Use a nonsteroidal blocker (Bridion label).
Monitoring
| Parameter | When / How Often | Target / Act If |
|---|---|---|
| Clinical: waveform EtCO₂ | Continuous from intubation through transport and handoff | Loss of waveform: assume tube displacement or circuit disconnection; the paralyzed patient cannot breathe alone |
| Clinical: SpO₂, ECG, BP | Continuous; frequent BP around intubation | Hypotension or bronchospasm after the push: consider anaphylaxis |
| Clinical: sedation and analgesia | Before the first dose and with every vital-sign set during paralysis | Goal deep sedation before and throughout; rising HR or BP, tearing: give analgesia and sedation |
| Neuromuscular: train-of-four | Before each repeat dose and each infusion titration | No twitch: do not redose. ICU/transport infusions: commonly 1–2 of 4 twitches, read with clinical signs (SCCM) |
| Neuromuscular: recovery | Before extubation or stopping ventilation | Quantitative TOF ratio ≥0.9 at the adductor pollicis; lower: reverse or keep ventilating (ASA guideline) |
| Clinical: neuro exam | Document before paralysis | Paralysis hides motor findings and convulsions; pupils still react. For adults after cardiac arrest who do not follow commands, AHA 2025 recommends prompt EEG for seizures (Part 11); after arrest, NMBAs may be metabolized more slowly and residual paralysis can confound the exam |
| Laboratory: acid-base, electrolytes, glucose | With ABG and chemistry on infusions | |
| Infusion safety | Every titration and every handoff | Confirm concentration, mcg/kg/min, weight used and a labeled line |
Interactions & Compatibility
Clinically Significant Interactions
| Drug / Class | Effect | What To Do |
|---|---|---|
| Inhaled anesthetics (isoflurane, enflurane) | Longer block; infusion needs fall about 40% | Reduce infusion 30–50% at steady state; TOF |
| Antibiotics: aminoglycosides, vancomycin, tetracyclines, bacitracin, polymyxins, colistin | Prolonged block | Expect a longer duration; TOF before redosing |
| Magnesium salts (e.g., pre-eclampsia, eclampsia) | Enhanced block | Lower repeat doses; TOF |
| Lithium, local anesthetics, procainamide, quinidine | Prolonged block; quinidine during recovery can cause recurrent paralysis | Monitor TOF and breathing after these drugs |
| Succinylcholine | Given first, rocuronium lasts longer (median 36 vs 28 min); rocuronium before succinylcholine not studied | Give rocuronium only after succinylcholine recovery is seen |
IV Compatibility
- Diluents: NS, D5W, D5NS, lactated Ringer's, sterile water (up to 5 mg/mL for 24 hr).
- Physically incompatible (label): many classes, including cephalosporins, penicillins, corticosteroids, benzodiazepines, vancomycin, furosemide, insulin, ketorolac and methohexital. Don't co-infuse them in one line.
- Alkaline solutions: never in the same syringe, and never through the same needle at once. Flush between drugs.
Special Populations
- Pediatrics: the label doesn't recommend rocuronium for pediatric RSI. Even so, it was the most used paralytic in a 13-center US pediatric RSI study. Onset is fastest in infants aged 28 days to 3 months, and duration is longest in infants. Post-intubation sedation is often late or missing. Doses are in the Pediatric Dosing table.
- Neonates: slowest onset and long duration. Follow NICU or specialist direction.
- Pregnancy: the label identifies no drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. It crosses the placenta. For Cesarean section RSI, the label does not recommend it. Magnesium for pre-eclampsia enhances the block. Don't withhold indicated emergency airway management.
- Lactation: there are no data on milk transfer or infant effects. Weigh the benefits of breastfeeding against the mother's need.
- Older adults: onset is slower (median 2.3 min at 0.6 mg/kg), and duration is longer (46, 62 and 94 min after 0.6, 0.9 and 1.2 mg/kg). Expect a higher risk of residual block. Monitor TOF and consider reversal.
- Renal impairment: Usual doses apply. Duration varies widely (22–90 min). Sugammadex is not recommended in severe renal impairment, dialysis included (Bridion label).
- Hepatic impairment: expect duration about 1.5 times longer. In cirrhosis, half-life about doubles.
- Obesity / dosing weight: the label bases the initial dose on actual body weight. Ideal-weight dosing gave slower onset and poorer intubating conditions. At 1–1.2 mg/kg, paralysis can be very long, so have sugammadex available. For ICU paralytic dosing, SCCM 2016 suggests a consistent ideal or adjusted body weight. Protocols vary.
- Myasthenia gravis: marked sensitivity. Use a reduced dose, guided by TOF.
- Low plasma cholinesterase: no adjustment. Rocuronium isn't metabolized by cholinesterase.
Field & Transport Considerations
- Scope: Credentialed paramedics for RSI, critical-care and flight teams, and RNs under orders. It varies by state and agency protocol.
- Storage: Refrigerate multiple-dose vials at 2–8 °C (36–46 °F). Never freeze them. At room temperature (25 °C), use within 60 days. Use opened vials within 30 days. Date the vial when it leaves the refrigerator. For room-temperature single-dose products, follow the package.
- Carried concentration: one strength (10 mg/mL). The real danger is grabbing the wrong drug. Keep it in a separate, labeled paralytic pouch, never beside look-alike small vials.
- After intubation and in transport: start sedation and analgesia within minutes. Confirm continuous EtCO₂ and ventilator alarms. Secure the tube and circuit before every move (SCCM good practice). Run infusions on a smart pump with a drug library, on a labeled dedicated line.
- Handoff: time, dose in mg and mg/kg and weight used for rocuronium and the induction agent; expected offset; last sedation and analgesia doses; any sugammadex given; TOF result; pre-paralysis neuro exam.
Clinical Pearls
Rocuronium vs succinylcholine (NREMT, FP-C, CFRN):
- Succinylcholine: the fastest offset. It carries hyperkalemia and malignant hyperthermia risks.
- Rocuronium: no hyperkalemia. It's reversible with sugammadex, but it lasts far longer.
- In the prehospital CURASMUR trial (1,248 adults), first-pass success was 74.6% vs 79.4%. Rocuronium was not shown to be noninferior.
Sugammadex returns muscle, not the airway: Immediate reversal works in minutes. The patient is still sedated, though, and the upper airway can obstruct anyway. Don't hold off on a surgical airway while you wait for sugammadex.
Low cardiac output delays onset: With cardiovascular disease, advanced age or other prolonged circulation time, the drug reaches muscle slowly (label section 5.8). Let it finish. Wait for a slack jaw and no movement before laryngoscopy. Give it time instead of adding more drug.
ICU paralysis is a bundle (CCRN): Start with deep sedation. Judge the block by train-of-four plus clinical signs, not TOF alone. Add scheduled eye care, physiotherapy, a glucose target below 180 mg/dL (SCCM 2016 suggestion) with monitoring per ICU protocol, and a daily stop decision.
Sugammadex keeps binding rocuronium: after up to 4 mg/kg, rocuronium 1.2 mg/kg may be given after 5 min. After 4 hr, rocuronium 0.6 mg/kg may be given (24 hr with mild or moderate renal impairment). After 16 mg/kg, wait 24 hr or use a nonsteroidal blocker. Check the sugammadex page before any repeat dose.
Pharmacology
Mechanism of Action
- Competitive nicotinic acetylcholine receptor antagonist at the motor end-plate. The result is flaccid paralysis without fasciculations.
- No effect on consciousness, pain threshold or cerebration: sedation and analgesia are always required.
- Dose-dependent onset: ED95 is about 0.3 mg/kg. RSI doses (3–4 times ED95) speed onset but prolong duration.
- Mild vagolytic effect: expect occasional tachycardia. Minimal histamine release.
Pharmacokinetics
| Route | Onset | Peak | Duration |
|---|---|---|---|
| IV, 0.6 mg/kg | About 1 min (median, to intubating block) | Most patients under 3 min | 31 min (15–85) |
| IV, 1.2 mg/kg | Intubating conditions in most patients within 2 min (0.6–1.2 mg/kg range) | Not separately labeled | 67 min (38–160) |
| IO | No labeled data; dosed as IV | — | — |
- Half-life: distribution 1–2 min and 14–18 min. Elimination is about 1.4 hr in adults under opioid/N₂O anesthesia, about 0.7–1.3 hr in children (longest in infants), and about doubled in hepatic dysfunction. After a bolus, offset is mainly redistribution.
- Metabolism and elimination: metabolism is minimal. 17-desacetylrocuronium is rarely detected and weak. Elimination is mainly hepatic (biliary), with limited renal.
- Protein binding / Vd: about 30%; 0.25 L/kg (higher in cirrhosis and neonates).
Names & Classification
- Generic Name
- Rocuronium bromide
- Brand Names
- Zemuron (original US brand, discontinued); multiple generics
- Pharmacologic Class
- Nondepolarizing neuromuscular blocking agent (aminosteroid)
- Therapeutic Class
- Skeletal muscle relaxant (paralytic) for intubation and ventilation
- Controlled Substance
- Not controlled
- ISMP High-Alert
- Yes: ISMP high-alert medication (neuromuscular blocking agents)
- Look-Alike / Sound-Alike
- No tall-man pair; the main error is selecting a paralytic in place of another injectable, or giving it to the wrong patient
References
- Hospira, Inc. (2025). Rocuronium bromide injection, for intravenous use: Prescribing information (revised 06/2025). DailyMed, U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=309aeb1b-8022-4df7-8194-ae6529e3395c
- Fresenius Kabi USA, LLC. (2026). Rocuronium bromide injection, for intravenous use: Prescribing information (single-dose vials and prefilled syringes, NDA 217472; revised 07/2026). DailyMed, U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=04c9812d-5aa3-4949-ad02-c618028f1bb0
- Merck Sharp & Dohme LLC. (2026). BRIDION (sugammadex) injection, for intravenous use: Prescribing information (revised 03/2026). https://www.merck.com/product/usa/pi_circulars/b/bridion/bridion_pi.pdf
- Thilen, S. R., Weigel, W. A., Todd, M. M., Dutton, R. P., Lien, C. A., Grant, S. A., et al. (2023). 2023 American Society of Anesthesiologists practice guidelines for monitoring and antagonism of neuromuscular blockade. Anesthesiology, 138(1), 13–41. https://doi.org/10.1097/ALN.0000000000004379
- Murray, M. J., DeBlock, H., Erstad, B., Gray, A., Jacobi, J., Jordan, C., et al. (2016). Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient (Society of Critical Care Medicine). Critical Care Medicine, 44(11), 2079–2103. https://doi.org/10.1097/CCM.0000000000002027
- Qadir, N., Sahetya, S., Munshi, L., Summers, C., Abrams, D., Beitler, J., et al. (2024). An update on management of adult patients with acute respiratory distress syndrome: An official American Thoracic Society clinical practice guideline. American Journal of Respiratory and Critical Care Medicine, 209(1), 24–36. https://doi.org/10.1164/rccm.202311-2011ST
- Guihard, B., Chollet-Xémard, C., Lakhnati, P., Vivien, B., Broche, C., Savary, D., et al. (2019). Effect of rocuronium vs succinylcholine on endotracheal intubation success rate among patients undergoing out-of-hospital rapid sequence intubation: A randomized clinical trial (CURASMUR). JAMA, 322(23), 2303–2312. https://doi.org/10.1001/jama.2019.18254
- Bisesi, S. A., Stauber, S. D., Hutchinson, D. J., & Acquisto, N. M. (2024). Current practices and safety of medication use during pediatric rapid sequence intubation. Journal of Pediatric Pharmacology and Therapeutics, 29(1), 66–75. https://doi.org/10.5863/1551-6776-29.1.66
- Grasselli, G., Calfee, C. S., Camporota, L., et al. (2023). ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies. Intensive Care Medicine, 49(7), 727–759. https://doi.org/10.1007/s00134-023-07050-7
- Papazian, L., Forel, J.-M., Gacouin, A., et al. (2010). Neuromuscular blockers in early acute respiratory distress syndrome (ACURASYS). New England Journal of Medicine, 363(12), 1107–1116. https://pubmed.ncbi.nlm.nih.gov/20843245/
- National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, Moss, M., Huang, D. T., et al. (2019). Early neuromuscular blockade in the acute respiratory distress syndrome (ROSE). New England Journal of Medicine, 380(21), 1997–2008. https://pubmed.ncbi.nlm.nih.gov/31112383/
- Hirsch, K. G., Amorim, E., Coppler, P. J., et al. (2025). Part 11: Post-Cardiac Arrest Care: 2025 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation, 152(suppl 2), S673–S718. https://doi.org/10.1161/CIR.0000000000001375. Guideline page: https://cpr.heart.org/en/resuscitation-science/cpr-and-ecc-guidelines/post-cardiac-arrest-care
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