Bedside Snapshot
- Recognize
- Cold shock: normal BP with tachycardia, prolonged capillary refill, cool or mottled skin, weak pulses.
Warm shock: flushed skin, flash refill, bounding pulses.
Hypotension is a late sign. - Red Flags
- Lethargy or unresponsiveness
- Mottling; capillary refill over 2 s
- Falling urine output
- Bradycardia with poor perfusion
- First Actions
- Airway, oxygen, IV or IO access, glucose. Cultures and lactate, then antibiotics within 1 hr in suspected septic shock. Do not wait for cultures
- Key Doses
- Isotonic crystalloid 10–20 mL/kg bolus, reassess after each (up to 40–60 mL/kg in the first hour)
- Epinephrine or norepinephrine infusion if fluid-refractory
- Don't Miss
- Ductal-dependent heart disease in a neonate (PGE1 0.05–0.1 mcg/kg/min); tension pneumothorax; tamponade; fluid overload in cardiogenic shock
- Escalate & Transport
- Early PICU or pediatric-ready ED consult; transfer with a running infusion log in mcg/kg/min; structured handoff
Overview & Pediatric Differences
Shock is oxygen delivery that falls short of what the body needs. In children, heart rate is the main lever. The heart speeds up to push more blood out, so a child can hold a normal blood pressure while perfusion is already failing. Your job is to catch compensated shock (normal BP, poor perfusion) before it becomes decompensated shock (hypotension).
Why Kids Are Different
- Heart rate compensates: a small heart moves only so much blood per beat. Tachycardia is the early fix for volume loss or low output.
- Vasoconstriction masks loss: the pipes clamp down at the periphery and keep central pressures near normal. That holds until the reserve runs out.
- Small size, large surface area: infants lose water and heat fast through the skin. Vomiting and diarrhea make it worse.
- Late signs are abrupt: hypotension often shows up only after a sudden fall. Bradycardia with poor perfusion is a pre-arrest sign.
Pediatric arrest is most often respiratory in origin. Use the cardiac arrest page for that pathway.
Recognition & Severity
One vital sign won't tell you. Read the trend across several signs. Compare the child with their own baseline and age norms (see vital signs by age).
| Feature | Compensated Shock | Decompensated Shock |
|---|---|---|
| Blood pressure | Normal for age, or high-normal with a rising HR | Hypotension below the age threshold (see below) |
| Heart rate | Tachycardia | Tachycardia, or bradycardia with poor perfusion (pre-arrest) |
| Mental status | Irritable, anxious or restless | Lethargic, obtunded or unresponsive |
| Capillary refill | Prolonged (more than 2 s) | Markedly prolonged or absent |
| Skin | Cool, pale or mottled extremities | Gray or mottled, cold centrally |
| Pulses | Central pulses strong, peripheral pulses weak | Central pulses weak, peripheral pulses absent |
| Urine output | Reduced | Minimal or absent |
Age-Specific Presentation
- Neonate (0–28 days): poor feeding, lethargy, tachypnea, gray color, and a weak femoral pulse. Keep sepsis and ductal-dependent congenital heart disease on the list.
- Infant (1–12 months): irritability, poor feeding, sunken fontanelle and fewer wet diapers.
- Child (1–12 years): thirst, lethargy, cool extremities, abdominal pain or vomiting, and less urine.
- Adolescent (13–18 years): hypotension shows up later, then drops fast. Use adult shock signs and adult thresholds.
Cold vs Warm Shock
Warm (distributive) shock is more common in older kids and adults. It still happens in children, often as septic shock. Kids don't always fit one pattern, so judge the trend.
| Feature | Cold (vasoconstricted) | Warm (distributive) |
|---|---|---|
| Skin | Cool, pale or mottled | Warm, flushed |
| Capillary refill | Prolonged, more than 2 s | Flash, under 1 s |
| Pulses | Weak peripheral pulses | Bounding pulses |
| Pulse pressure | Narrow | Wide, with low diastolic pressure |
You don't need capillary refill over 2 s to diagnose shock. A warm child with flash refill can still be in shock. Pick the vasoactive drug by clinical picture and local protocol, not by warm or cold alone.
Hypotension Thresholds
- Term neonate: systolic BP below 60 mmHg
- Infant (1–12 months): systolic BP below 70 mmHg
- Child (1–10 years): systolic BP below 70 + (2 × age in years) mmHg
- Above 10 years: systolic BP below 90 mmHg
Under the 2024 Phoenix pediatric criteria, sepsis is suspected infection with a Phoenix score of 2 or more points across the respiratory, cardiovascular, coagulation and neurologic systems. Septic shock adds at least one cardiovascular organ-dysfunction point. That point comes from vasoactive medication count, lactate or age-based mean arterial pressure. The consensus criteria replace the older SIRS-based pediatric definitions.
Differential Diagnosis
| Condition | Distinguishing Features | Key Test or Finding |
|---|---|---|
| Hypovolemia | Vomiting, diarrhea, burns, bleeding or poor intake; weight loss; dry mucosa | History of losses; electrolytes, BUN and creatinine; glucose |
| Septic shock | Fever or hypothermia, a source, altered mental status, mottling | Lactate; cultures; glucose; CBC. Purpura suggests meningococcal disease |
| Anaphylaxis | Hives, angioedema, wheeze or stridor after exposure | Clinical picture; epinephrine IM for early treatment |
| Myocarditis or cardiomyopathy | Viral prodrome, gallop, hepatomegaly, poor perfusion out of proportion to the illness | ECG; echocardiogram; BNP per specialist |
| Ductal-dependent heart lesion (neonate) | Day 1 to 2 weeks of age; poor feeding; cyanosis; weak femoral pulses | Pre- and post-ductal SpO₂ difference; echocardiogram |
| Arrhythmia | Very fast or very slow rate with poor perfusion | Rhythm strip or 12-lead ECG |
| Obstructive lesion | Tension pneumothorax or pericardial tamponade (muffled heart sounds, distended neck veins) | Asymmetric breath sounds; ultrasound; ECG |
| Adrenal crisis or toxic cause | Known steroid dependence or adrenal insufficiency; ingestion history | Glucose and sodium; toxicology per local protocol |
Management by Type: Hypovolemic
- Give isotonic crystalloid: 10–20 mL/kg IV or IO as a push over 5–20 min (Paramedic/RN/CCT, per local protocol). Do not rely on a gravity drip in shock.
- Reassess after each bolus: HR, capillary refill, mental status, pulses, BP trend, SpO₂, work of breathing and lung exam, and urine output.
- Repeat as perfusion demands: SSC 2026 supports up to 40–60 mL/kg in the first hour, given as 10–20 mL/kg boluses. Stop when shock resolves or fluid overload develops (crackles, hepatomegaly, rising oxygen need).
- Hemorrhage: control external bleeding, and involve surgery for intra-abdominal or pelvic bleeding. Give blood products early in hemorrhagic shock per the trauma or transfusion protocol. Tranexamic acid and massive transfusion protocol activation are per the trauma protocol; product ratios and any permissive-hypotension target are protocol-dependent, and no fixed blood volume is given here.
- Treat the cause: antiemetic and oral or IV rehydration plans for gastroenteritis; DKA fluid management per the DKA protocol; burns per burn protocol.
Management by Type: Septic
0–5 Minutes
- Recognize and access: obtain IV or IO access (Paramedic/RN/CCT, per protocol). Check glucose.
- Draw labs without delay: blood culture, lactate, CBC, BMP and coagulation studies. SSC 2026 recommends measuring lactate as part of the initial evaluation.
Within 1 Hour
- Give antibiotics: in septic shock, start them as soon as possible, ideally within 1 hour of recognition. SSC 2026 strongly recommends this. Don't wait for culture results. Empiric choice follows local sepsis protocol and risk factors, which may add vancomycin for MRSA or meningitis coverage. Probable sepsis without shock gets a time-limited rapid evaluation first, then antimicrobials as soon as possible, ideally within 3 hours of recognition (conditional recommendation).
- Give fluid (septic shock with hypotension): 10–20 mL/kg balanced or buffered crystalloid per bolus, reassessing after each. SSC 2026 suggests balanced solutions over 0.9% saline. With ICU access, up to 40–60 mL/kg in the first hour. Without ICU access, up to 40 mL/kg in 10–20 mL/kg boluses over the first hour. Sepsis without hypotension and without ICU access? Don't give boluses. Start maintenance fluids (SSC 2026 strong recommendation).
After Fluid-Refractory Shock
- Start a vasoactive infusion: epinephrine or norepinephrine. SSC 2026 found insufficient evidence to prefer one over the other, so choose by clinical picture and local protocol. Dopamine is second-line here (see the dopamine page). Start peripherally or IO while central access is placed, and watch the site for extravasation.
- Add vasopressin or titrate catecholamines: SSC 2026 suggests this when high-dose catecholamines are needed. Vasopressin use in children is PICU specialist practice.
- Hydrocortisone: give stress-dose hydrocortisone when adrenal insufficiency is suspected or known. SSC 2026 suggests against routine IV hydrocortisone when fluids and vasoactive therapy restore stability.
- Intubation: if intubation is needed, resuscitate first and have a vasoactive ready. SSC 2026 suggests against etomidate for intubating children with sepsis (conditional recommendation).
- Escalate: PICU consultation and transfer. Add an inotrope if cardiac dysfunction persists (see the cardiogenic section).
Anaphylactic and Neurogenic Shock
- Anaphylaxis: epinephrine IM 0.01 mg/kg of 1 mg/mL, max 0.3 mg (prepubertal) or 0.5 mg (adolescent), repeat every 5–15 min (Epinephrine 1 mg/mL (IM)). Add a fluid bolus. If it stays refractory, start an epinephrine infusion, per protocol.
- Neurogenic shock: a spinal cord injury opens the pipes wide, often with bradycardia and no tachycardia. Go easy on fluids. Restore perfusion with a vasopressor (norepinephrine or phenylephrine) per protocol.
Management by Type: Cardiogenic & Obstructive
Cardiogenic Shock
- Myocarditis: a viral illness, then sudden decompensation. Give cautious 5–10 mL/kg boluses and reassess each one. Large volumes can worsen pulmonary edema.
- Inotropes: milrinone or dobutamine, specialist use only (PICU or cardiology). No pediatric dose is established for either (AHA 2025 Part 8 names both with no dose). Add a vasopressor if MAP is low.
- Arrhythmia: SVT is a common cause of shock in infants. Treat the rhythm per the pediatric tachycardia or bradycardia algorithm (Paramedic/RN/CCT, per protocol).
- Post-cardiac-surgery low output: treat with the cardiac team's inotrope and vasoactive plan.
Ductal-Dependent Lesions (Neonate)
- Consider the diagnosis: if a neonate in shock doesn't respond to fluid and antibiotics, think ductal-dependent heart lesion.
- Start alprostadil (PGE1): 0.05–0.1 mcg/kg/min IV (or umbilical artery catheter per label); IO only per specialist or protocol when no other access exists. Then reduce to the lowest effective rate (usually 0.01–0.1 mcg/kg/min). Specialist-directed.
- Monitor for apnea: about 10–12% of neonates with congenital heart defects get apnea on PGE1 (boxed warning), and it is most common under 2 kg at birth. Have airway and ventilation equipment ready before you start.
- Oxygen: in suspected ductal-dependent lesions, too much oxygen is a trap here. Titrate to avoid hyperoxia. High FiO₂ may promote ductal closure or pulmonary overcirculation in some lesions. Use pre- and post-ductal SpO₂ and specialist advice.
Obstructive Shock
- Tension pneumothorax: needle decompression followed by chest tube, per protocol. Do not wait for a chest X-ray in an unstable child.
- Cardiac tamponade: pericardial drainage by a specialist. Look for muffled heart sounds and distended neck veins.
- Massive pulmonary embolism: rare in children and more often seen with central lines. Specialist decision on thrombolysis.
Medications & Dosing
| Drug | Dose & Route | Max | Notes |
|---|---|---|---|
| Isotonic crystalloid (0.9% NaCl or lactated Ringer's) | 10–20 mL/kg IV/IO bolus over 5–20 min, reassess after each |
40–60 mL/kg in first hour with ICU access; without ICU, up to 40 mL/kg only in septic shock with hypotension |
Balanced crystalloid suggested over 0.9% saline (the SSC 2026 guideline). Lactated Ringer's contains calcium: never run it at the same time as ceftriaxone. Stop with fluid overload. See Normal Saline and Lactated Ringer's |
| Epinephrine infusion High-alert |
0.05–0.3 mcg/kg/min IV/IO, titrate to perfusion and age-based BP |
Differs: PICU practice titrates higher (to 1 mcg/kg/min); specialist use |
Pump in mcg/kg/min, not mcg/min. Pediatric range per the epinephrine page (NASEMSO Shock p. 109). Not a 1 mg IV push |
| Norepinephrine infusion High-alert |
0.05–0.5 mcg/kg/min IV/IO, titrated to physiologic targets (SBP at least the 5th percentile for age, strong distal pulses, capillary refill under 2 sec) |
Differs: PICU practice titrates above 0.5 mcg/kg/min (to 2); specialist use. Not FDA-established (label) |
Check the site for extravasation; phentolamine per local protocol. Wean once MAP and perfusion are adequate |
| Vasopressin High-alert |
Specialist use only: 0.0005–0.002 units/kg/min IV (off-label; RCT range, Choong 2009) |
Do not exceed the adult dose (NASEMSO Universal Care p. 13) |
Add-on when high-dose catecholamines are needed (the SSC 2026 guideline). Not established in children (US label). No benefit shown in the RCT; not for pediatric cardiac arrest (AHA 2025 has no pediatric vasopressin recommendation) |
| Dopamine infusion High-alert |
Start 2–5 mcg/kg/min IV/IO, titrate in 5–10 mcg/kg/min steps |
Usual max 15–20 mcg/kg/min (premix) |
Second-line here. Tachyarrhythmias and ectopy are common. Extravasation: phentolamine per local protocol, and check the site |
| Milrinone High-alert |
Specialist use only: no house dose (not established in children, US label; AHA 2025 Part 8 names milrinone with no dose) |
No house dose |
Low-output shock with cardiac dysfunction. Give with a vasopressor if MAP is low. Hypotension is a limit |
| Dobutamine High-alert |
Specialist use only: no house dose (vial label: pediatric safety and effectiveness not established) |
No house dose |
Cardiogenic shock with low output. Watch for tachycardia and new arrhythmia |
| Hydrocortisone Selected shock only |
Suspected or known adrenal insufficiency: 2 mg/kg IV or IM bolus (IO off-label) |
Bolus max 100 mg. Weight unknown: length-based tape |
Use for adrenal insufficiency, long-term steroid dependence, or fluid-refractory shock requiring vasopressors. Hydrocortisone is preferred over methylprednisolone and dexamethasone in adrenal insufficiency. Not routine when fluids and vasoactive therapy restore stability (the SSC 2026 guideline). Ongoing dosing: see the Hydrocortisone page. |
| Dextrose 10% (D10W) | 5–10 mL/kg IV/IO (0.5–1 g/kg) for hypoglycemia; neonates 2 mL/kg, then infusion |
Max 25 g per dose |
Recheck glucose after each dose. Do not use D50 under 8 years |
| Ceftriaxone (empiric example, children over 28 days) | 50–75 mg/kg/day IV/IM for serious infection, per sepsis protocol; suspected meningitis 100 mg/kg/day IV |
Max 2 g/day for serious infection; meningitis max 4 g/day |
Give within 1 hour of recognition in septic shock; empiric choice per local protocol. Contraindicated in neonates 28 days or younger receiving or expected to receive calcium-containing IV solutions (including lactated Ringer's, TPN, IV calcium), and in premature or hyperbilirubinemic neonates. Never run at the same time in the same line at any age; flush between doses. Neonates: ampicillin plus gentamicin or cefotaxime is usual, per protocol |
| Alprostadil (PGE1) infusion Specialist use |
0.05–0.1 mcg/kg/min IV start (or umbilical artery catheter per label); maintain at 0.01–0.1 mcg/kg/min |
Label max 0.4 mcg/kg/min |
Ductal-dependent lesions only. Apnea in about 10–12% of neonates with congenital heart defects, most often under 2 kg (boxed warning). Titrate oxygen to avoid hyperoxia. Have airway equipment ready. IO only per specialist |
Pediatric doses come from three sources, in this order. First AHA/AAP 2025, where it states a dose. Then the NASEMSO National Model EMS Clinical Guidelines v3.0 (2022). Then the US label. Where none of them gives a dose, none is shown. No pediatric maximum ever goes above the adult maximum dose (NASEMSO Universal Care Guideline, p. 13). Unless marked labeled, the dose is off-label. Dose on actual body weight, in kg. Calculate mL/hr as dose (mcg/kg/min) × weight (kg) × 60 ÷ concentration (mcg/mL).
Monitoring, Reassessment & Disposition
| Parameter | Target | Notes |
|---|---|---|
| Perfusion | Capillary refill 2 s or less; warm extremities; normal mental status | Reassess after each bolus and frequently during active resuscitation (interval per protocol) |
| Blood pressure | Age-appropriate; not a single target | Judge BP together with perfusion and trend |
| Urine output | Adequate for weight | Foley catheter for accurate measurement in critically ill children |
| Lactate | Falling with treatment | Measure and trend. SSC 2026 gives no fixed threshold |
| Glucose | Treat per local protocol (commonly below 60 mg/dL in children; neonates per neonatal protocol, commonly below 45–50 mg/dL) | D10W for hypoglycemia (see medications table) |
| Oxygenation | Avoid hypoxemia and hyperoxia | Titrate oxygen to SpO₂ per local protocol |
| Temperature | Normothermia | Warm fluids; monitor core temperature during large volumes |
- Labs: lactate, glucose, electrolytes, BUN and creatinine, CBC, coagulation studies (DIC is common in septic shock), and blood gas with base deficit. Trend the base deficit on serial gases. Forget the fixed cutoff.
- Disposition: PICU or a pediatric-ready ED. Transfer early. Ideally, move the child before they're on multiple infusions or intubated.
Pitfalls & Safety Checks
| Pitfall | Consequence | Prevention |
|---|---|---|
| Treating hypotension as the first sign | Late recognition; sudden collapse | Act on perfusion signs and the trend, not the BP number |
| Slow drip boluses | Shock is not reversed | Push 10–20 mL/kg and reassess after each |
| Fluid overload in cardiogenic shock | Pulmonary edema; worse output | Small boluses (5–10 mL/kg); stop at crackles or hepatomegaly |
| Waiting for cultures before antibiotics | Delayed treatment of septic shock | Draw cultures, then give antibiotics without delay |
| Infusion units confused | Dosing errors by a large factor | Check mcg/kg/min on the pump and the dosing weight |
| Giving pediatric doses by age instead of weight | Over- or underdosing | Use measured weight, then a length-based estimate (see the broselow page) |
| Starting a PGE1 infusion without airway readiness | Apnea in neonates | Airway equipment and ventilation ready before starting |
| Missing hypoglycemia | Seizure; worsening shock | Check glucose in every child with shock |
Special Populations
Neonates and Young Infants
- Two shock types can look alike: sepsis and ductal-dependent heart disease. No response to fluid and antibiotics? Consider the second.
- Check glucose early and repeatedly. Use D10W 2 mL/kg for a neonate.
- Neonatal septic shock: ampicillin plus gentamicin or cefotaxime per neonatal protocol. Consider acyclovir when HSV is possible in a febrile or ill neonate. Ceftriaxone is contraindicated in neonates 28 days or younger who need calcium-containing IV solutions.
Adolescents
- Switch point: at 40 kg or more, or beyond the length-based tape, use adult protocols and adult dose maximums. Follow local protocol.
Children With Special Health Care Needs
- Carry the Emergency Information Form: it lists the central line, VP shunt, gastrostomy, tracheostomy and home medications.
- Ask about steroids: long-term or recent steroid use points to adrenal suppression. That changes the fluid and hydrocortisone plan.
Congenital Heart Disease
- Ask about prior surgery: single-ventricle physiology and Fontan circulation don't tolerate hypovolemia or arrhythmia well. Call cardiology early.
Prehospital & Transport Considerations
| Level | Typical Role in Pediatric Shock |
|---|---|
| EMT | Recognize shock, position, oxygen, keep warm, early transport to a pediatric-ready ED |
| AEMT | IV or IO access, glucose check, fluid bolus per protocol (commonly) |
| Paramedic | IO access, 10–20 mL/kg bolus with reassessment, vasoactive infusion per protocol (commonly) |
| RN (ED/ICU) | Titrate infusions, lab draws, antibiotics within 1 hour, PICU consult |
| Critical care transport | Infusion pumps, mcg/kg/min dosing, altitude effects on infusions and ventilation, en-route PICU support |
- Prepare the drugs: pre-drawn or color-coded bolus syringes; pump programmed in mcg/kg/min with the dosing weight written on the label.
- Choose the destination: the nearest pediatric-ready ED for initial stabilization, or PICU when escalation is expected.
- Restrain on the stretcher: use a size-appropriate restraint. Do not hold the child on a caregiver's lap during transport.
- Vasoactives and airway: a peripheral or IO vasoactive start is acceptable while central access is placed. Watch the site for extravasation. If intubation is needed, resuscitate first and have a vasoactive ready. SSC 2026 suggests against etomidate.
- Keep the child warm: infants lose heat fast. Warm the fluids when feasible.
- Handoff: use a structured format (IMIST-AMBO or MIST) and state the fluids given in mL/kg and the time of each bolus.
Clinical Pearls
References
- Weiss SL, Peters MJ, Oczkowski SJW, et al. Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026. Pediatr Crit Care Med. 2026;27:379–434. https://doi.org/10.1097/PCC.0000000000003927
- Sanchez-Pinto LN, Bennett TD, DeWitt PE, et al. Development and validation of the Phoenix criteria for pediatric sepsis and septic shock. JAMA. 2024;331:675–686. https://doi.org/10.1001/jama.2024.0196
- Schlapbach LJ, Watson RS, Sorce LR, et al. International consensus criteria for pediatric sepsis and septic shock. JAMA. 2024;331:665–674. https://doi.org/10.1001/jama.2024.0179
- Lasa JJ, Dhillon GS, Duff JP, et al. Part 8: Pediatric Advanced Life Support: 2025 American Heart Association and American Academy of Pediatrics Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2025;152:S479–S537. https://doi.org/10.1161/CIR.0000000000001368
- Pharmacia & Upjohn. PROSTIN VR Pediatric (alprostadil) injection, prescribing information. DailyMed; 2026. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=930f8c02-46a8-4cff-a484-660468ab23c3
Medical Disclaimer
- For Educational Purposes Only: This content is intended for educational reference and should not be used for clinical decision-making.
- Not a Substitute for Professional Judgment: Always consult your local protocols, institutional guidelines, and supervising physicians.
- Verify Before Acting: Users are responsible for verifying information through authoritative sources before any clinical application.